Combination therapy vs single-target therapy

I feel that single-target drugs are getting harder to make. I remember years back, when there were three AIDS drugs going through clinical trials. We were all shocked when all of them failed. But some smart soul realized that when combined, the three were a miracle cocktail. Indeed, fast forward to the present and this […]

Mixing meaning into disease research – Treato

I wasn’t so sure how to describe Treato. It’s really interesting – mixing semantic analysis, social media, medical records, and analysis – Treato is really the next level of how consumers research diseases. The image to the right is one that came from searching for Lyme disease. I am not sure how they assemble that […]

We interrupt our usual program …… Down With Everything

Thomas Friedman recently wrote about a discussion he had with Frank Fukyama on the two-volume opus Fukyama is working on “The Origins of Political Order.” Of course, I hardly ever get political here, but this article resonated with me. “Indeed, America today increasingly looks like the society that the political scientist Mancur Olson wrote about […]

Repeated evolution in sticklebacks, and adjacent possibles

“Researchers have documented repeated evolution in other organisms, but the sticklebacks are unique because the freshwater transition has occurred so many times. “Sticklebacks have been a phenomenal system for understanding rapid evolution,” says evolutionary biologist Erica Bree Rosenblum of the University of California, Berkeley, who wasn’t involved in the study. “This paper shows that repeated […]

The wacky world of horizontal gene transfer, genomic variants, and what we think are microbial species

“The main difference from eukaryotes is that prokaryotic reproduction is independent of DNA acquisition and recombination. Instead, DNA is obtained from fragmented chromosomes obtained via parasexual means (that is, without reproduction). These mechanisms of DNA exchange are not restricted to gene exchange within species, and therefore traits can and do come from highly divergent organisms. […]

New Old Publishing and “The New Value of Text”

“Finally, the text still requires context. As publishers spin up their digital and print-on-demand backlists, more and more is published with less and less context. These efforts amount to land-grabs and rights-squatting, without adding value. Works without TOCs, indexes, author bios, footnotes. Placing work in context is one of publishers’ primary tasks, stretching out to […]