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Month: March 2012

Links of note/Science/The Narrative

International Human Microbe Program Looks Ahead – ScienceInsider

Posted on 30 March 2012 by charlie

Indeed, Sharp said at the meeting, patients who come to Cleveland Clinic for treatment of inflammatory bowel disease express their own concerns about such appro...

Science/The Narrative

Microbiome sequencing offers hope for diagnostics : Nature News & Comment

Posted on 27 March 2012 by charlie

“Jonathan Eisen [@phylogenomics], a microbiologist at University of California, Davis, is worried that microbiome research will eventually encounter the s...

Links of note/Science/The Narrative

Dangerous C. difficile infections soar in US, but Massachusetts hospitals have cut germ’s spead – The Boston Globe

Posted on 23 March 2012 by charlie

“A life-threatening germ that causes diarrhea and spreads easily from doctors’ offices to hospitals and nursing homes has climbed to historic highs nation...

Links of note/Science

A human gut microbial gene catalogue established by metagenomic sequencing : Nature

Posted on 22 March 2012 by charlie

“Beyond providing the global view of the human gut microbiome, the extensive gene catalogue we have established enables future studies of association of t...

Links of note/Science

Genome Sequence of E. coli O104:H4 Leads to Rapid Development of a Targeted Antimicrobial Agent against This Emerging Pathogen – PLoS ONE

Posted on 22 March 2012 by charlie

“A recent widespread outbreak of Escherichia coli O104:H4 in Germany demonstrates the dynamic nature of emerging and re-emerging food-borne pathogens, par...

Links of note/Science

Bacterial genomics: A new source of antimicrobial targets : Nature Reviews Microbiology

Posted on 21 March 2012 by charlie

“Bacterial clone-based genome sequencing frequently results in gaps, which harbour hypothetical genes of unknown function. Sorek and colleagues show that ...

Links of note/Science/Strategy

A Method for Generation Phage Cocktail with Great Therapeutic Potential – PLoS ONE

Posted on 21 March 2012 by charlie

“Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant varian...

Links of note/Science/The Narrative

Macro and Micro Diversity of Clostridium difficile Isolates from Diverse Sources and Geographical Locations – PLoS ONE

Posted on 19 March 2012 by charlie

“Clostridium difficile has emerged rapidly as the leading cause of antibiotic-associated diarrheal disease, with the temporal and geographical appearance ...

Innovation/Links of note/Science/Strategy

Broad Institute Gets $32.5 Million to Map Cell Circuits – ScienceInsider

Posted on 14 March 2012 by charlie

“The Broad isn’t alone: Mount Sinai School of Medicine in New York City, the Allen Institute for Brain Science in Seattle, the Salk Institute in San...

Links of note/Science/Strategy

Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum – PLoS Pathogens

Posted on 13 March 2012 by charlie

This paper is trying to measure and model the effectiveness of multi-drug antimicrobial chemotherapy. Antibiotics are notorious for losing effectiveness as the ...

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