Saturday morning thoughts on the evolutionary history of IBD in Eastern European Jews

Of course, as is usual with me on the weekend, I started reading all my open tabs in my browser. And the first one I read was a paper where they crossed two pure strains of mice and correlated microbiome and genome. Link: PLoS ONE: Murine Gut Microbiota Is Defined by Host Genetics and Modulates […]

Another article on “Patterns of Early Gut Colonization Shape Future Immune Responses of the Host” in PLoS ONE

“In conclusion, a time window exists that enables the artificial colonization of GF mice by a single oral dose of caecal content, which may modify the future immune phenotype of the host. Moreover, delayed microbial colonization of the gut causes permanent changes in the immune system.” Ok. So there’s mounting evidence that rapid colonization of […]

The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins

“The results also showed that (i) consumption of an FMP containing five bacterial strains was not associated with a statistically significant change in the proportional representation of resident community members within and between individuals; (ii) the appearance and disappearance of strains comprising the FMP consortium did not exhibit familial patterns in the fecal microbiota; and […]

International Human Microbe Program Looks Ahead – ScienceInsider

Indeed, Sharp said at the meeting, patients who come to Cleveland Clinic for treatment of inflammatory bowel disease express their own concerns about such approaches, which could include the use of probiotics, the consumption of live microorganisms, to treat intestinal and other maladies. “Many patients are worried about manipulating their gut microbiota,” Sharp said, adding […]

Microbiome sequencing offers hope for diagnostics : Nature News & Comment

“Jonathan Eisen [@phylogenomics], a microbiologist at University of California, Davis, is worried that microbiome research will eventually encounter the same backlash. “Without a doubt we are running into some of the same problems as the Human Genome Project,” he says. “There are many people who have oversold the human microbiome as the cause or cure […]

A human gut microbial gene catalogue established by metagenomic sequencing : Nature

“Beyond providing the global view of the human gut microbiome, the extensive gene catalogue we have established enables future studies of association of the microbial genes with human phenotypes and, even more broadly, human living habits, taking into account the environment, including diet, from birth to old age. We anticipate that these studies will lead […]

Session: The Earth Microbiome Project: Modeling the Microbial Planet (2012 AAAS Annual Meeting (16-20 February 2012))

“The Earth Microbiome Project (EMP) is the most ambitious attempt to provide a systematic characterization of the microbial world that dominates this planet. The ecosystem services provided by microbes in every environment (including the human body) are fundamental to the survival of life on this planet and the continued economic and physical health of the […]

Your Gut Bacteria Are What You Eat – ScienceNOW

“A large European-Asian consortium brought some order to the chaos when it reported in a Nature paper in April that humanity can be roughly divided into three “enterotypes” depending on which genus of bacteria dominates in people’s gut: Bacteroides, Ruminococcus, or Prevotella. People’s enterotype appeared to be stable over time, but it remains unclear why […]

Gut bacteria in Japanese people borrowed sushi-digesting genes from ocean bacteria | Discover Magazine

“Nori is, by far, the most likely source of bacteria with porphyran-digesting genes. It’s the only food that humans eat that contains any porphyrans and until recently, Japanese chefs didn’t cook nori before eating it. Any bacteria that lingered on the green fronds weren’t killed before they could mingle with gut bacteria like B.plebius. Ruth […]

Divided by language, united by gut bacteria – people have three common gut types | Discover Magazine

“Enterotypes aren’t quite as well-defined as, say, blood groups, but they could have similar uses as medical markers. The microbiome helps us to digest our food and it affects our susceptibility to diseases; the enterotypes could reflect these roles. Each enterotype was dominated by a specific genus of bacteria, and varied in the proportions of […]