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Category: Science

Links of note/Science

Genome Sequence of E. coli O104:H4 Leads to Rapid Development of a Targeted Antimicrobial Agent against This Emerging Pathogen – PLoS ONE

Posted on 22 March 2012 by charlie

“A recent widespread outbreak of Escherichia coli O104:H4 in Germany demonstrates the dynamic nature of emerging and re-emerging food-borne pathogens, par...

Links of note/Science

Bacterial genomics: A new source of antimicrobial targets : Nature Reviews Microbiology

Posted on 21 March 2012 by charlie

“Bacterial clone-based genome sequencing frequently results in gaps, which harbour hypothetical genes of unknown function. Sorek and colleagues show that ...

Links of note/Science/Strategy

A Method for Generation Phage Cocktail with Great Therapeutic Potential – PLoS ONE

Posted on 21 March 2012 by charlie

“Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant varian...

Links of note/Science/The Narrative

Macro and Micro Diversity of Clostridium difficile Isolates from Diverse Sources and Geographical Locations – PLoS ONE

Posted on 19 March 2012 by charlie

“Clostridium difficile has emerged rapidly as the leading cause of antibiotic-associated diarrheal disease, with the temporal and geographical appearance ...

Innovation/Links of note/Science/Strategy

Broad Institute Gets $32.5 Million to Map Cell Circuits – ScienceInsider

Posted on 14 March 2012 by charlie

“The Broad isn’t alone: Mount Sinai School of Medicine in New York City, the Allen Institute for Brain Science in Seattle, the Salk Institute in San...

Links of note/Science/Strategy

Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum – PLoS Pathogens

Posted on 13 March 2012 by charlie

This paper is trying to measure and model the effectiveness of multi-drug antimicrobial chemotherapy. Antibiotics are notorious for losing effectiveness as the ...

Links of note/Science/Strategy/The Narrative

Patterns of Gene Flow Define Species of Thermophilic Archaea: PLoS Biology

Posted on 12 March 2012 by charlie

“Patterns of homologous gene flow among genomes of 12 strains from a single hot spring in Kamchatka, Russia, demonstrate higher levels of gene flow within...

Links of note/Science/The Narrative

Influence of Milk-Feeding Type and Genetic Risk of Developing Coeliac Disease on Intestinal Microbiota of Infants: The PROFICEL Study

Posted on 11 March 2012 by charlie

“This study demonstrates that the milk-feeding type and the HLA-DQ genotype differently influence the bacterial colonization pattern of the newborn intest...

Links of note/Science/Strategy/The Narrative

Crowd-Sourcing Drug Discovery

Posted on 10 March 2012 by charlie

“The first challenge that OSDD’s cyber-community assigned itself was to glean more information from the M. tuberculosis genome. It was sequenced in ...

Links of note/Science/Strategy/The Narrative

Biodiversity of Indigenous Saccharomyces Populations from Old Wineries of South-Eastern Sicily: Preservation and Economic Potential

Posted on 09 March 2012 by charlie

“We report on the remarkable degree of biodiversity in the wine yeast populations naturally present in a small area of Sicily where traditional (non-indus...

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