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Category: Strategy

Links of note/Science/Strategy/The Narrative

The wacky world of horizontal gene transfer, genomic variants, and what we think are microbial species

Posted on 20 April 2012 by charlie

“The main difference from eukaryotes is that prokaryotic reproduction is independent of DNA acquisition and recombination. Instead, DNA is obtained from f...

Links of note/Strategy/The Narrative

Another article on “Patterns of Early Gut Colonization Shape Future Immune Responses of the Host” in PLoS ONE

Posted on 17 April 2012 by charlie

“In conclusion, a time window exists that enables the artificial colonization of GF mice by a single oral dose of caecal content, which may modify the fut...

Links of note/Strategy/The Narrative

New Old Publishing and “The New Value of Text”

Posted on 11 April 2012 by charlie

“Finally, the text still requires context. As publishers spin up their digital and print-on-demand backlists, more and more is published with less and les...

Innovation/Links of note/Science/Strategy/The Narrative

Gut microbes and immunity: The hygiene hypothesis, peak antibiotics, and the post-Pasteurian Age

Posted on 09 April 2012 by charlie

“Exposure to microbes during early childhood is associated with protection from immune-mediated diseases such as inflammatory bowel disease (IBD) and asth...

Links of note/Science/Strategy

A Method for Generation Phage Cocktail with Great Therapeutic Potential – PLoS ONE

Posted on 21 March 2012 by charlie

“Bacteriophage could be an alternative to conventional antibiotic therapy against multidrug-resistant bacteria. However, the emergence of resistant varian...

Innovation/Links of note/Science/Strategy

Broad Institute Gets $32.5 Million to Map Cell Circuits – ScienceInsider

Posted on 14 March 2012 by charlie

“The Broad isn’t alone: Mount Sinai School of Medicine in New York City, the Allen Institute for Brain Science in Seattle, the Salk Institute in San...

Links of note/Science/Strategy

Two-Drug Antimicrobial Chemotherapy: A Mathematical Model and Experiments with Mycobacterium marinum – PLoS Pathogens

Posted on 13 March 2012 by charlie

This paper is trying to measure and model the effectiveness of multi-drug antimicrobial chemotherapy. Antibiotics are notorious for losing effectiveness as the ...

Links of note/Science/Strategy/The Narrative

Patterns of Gene Flow Define Species of Thermophilic Archaea: PLoS Biology

Posted on 12 March 2012 by charlie

“Patterns of homologous gene flow among genomes of 12 strains from a single hot spring in Kamchatka, Russia, demonstrate higher levels of gene flow within...

Links of note/Science/Strategy/The Narrative

Crowd-Sourcing Drug Discovery

Posted on 10 March 2012 by charlie

“The first challenge that OSDD’s cyber-community assigned itself was to glean more information from the M. tuberculosis genome. It was sequenced in ...

Links of note/Science/Strategy/The Narrative

Biodiversity of Indigenous Saccharomyces Populations from Old Wineries of South-Eastern Sicily: Preservation and Economic Potential

Posted on 09 March 2012 by charlie

“We report on the remarkable degree of biodiversity in the wine yeast populations naturally present in a small area of Sicily where traditional (non-indus...

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